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"Wisecracking mercenary Deadpool meets Russell, an angry teenage mutant who lives at an orphanage. When Russell becomes the target of Cable -- a genetically enhanced soldier from the future -- Deadpool realizes that he'll need some help saving the boy from such a superior enemy. He soon joins forces with Bedlam, Shatterstar, Domino and other powerful mutants to protect young Russell from Cable and his advanced weaponry. After successfully working as the mercenary Deadpool for two years, Wade Wilson fails to kill one of his targets on his anniversary with his girlfriend Vanessa. That night, after the pair decides to start a family together, the target tracks them down and kills Vanessa. Wilson kills the man in revenge. He blames himself for her death and attempts to commit suicide six weeks later by blowing himself up. Wilson has a vision of Vanessa in the afterlife, but the pieces of his body remain alive and are put back together by Colossus. Wilson is left with only a Skee-Ball token, an anniversary gift, as a final memento of Vanessa.
Recovering at the X-Mansion, Wilson agrees to join the X-Men as a form of healing. He, Colossus, and Negasonic Teenage Warhead respond to a standoff between authorities and the unstable young mutant Russell Collins / Firefist at an orphanage, labeled a ""Mutant Reeducation Center"". Wilson realizes that Collins has been abused by the orphanage staff, and kills one of the staff members. Colossus stops him from killing anyone else, and both Wilson and Collins are arrested. Restrained with collars that suppress their powers, they are taken to the ""Ice Box"", an isolated prison for mutant criminals. Meanwhile, a cybernetic soldier from the future, Cable, whose family is murdered by an older Collins, travels back in time to kill the boy before Collins ever becomes a killer."
